How to alter the phenotype of a cell or an organism?

How to alter the phenotype of a cell or an organism?
With small molecules, peptides, or the  biological process called RNA interference (RNAi)  in which RNA molecules inhibit gene expression.

Where are the world's highest homicide rates located?

Where are the world's highest homicide rates located?

 

 

West Garfield Park, Chicago, Illinois, a homicide rate of 116 per 100,000 people.

Honduras, a homicide rate of 90.

West Englewood , Chicago, Illinois, a homicide rate of 73.3

Chatham, Chicago, Illinois, a homicide rate of 58.

Venezuela, a homicide rate of  53.7 rate.

Englewood ,  Chicago, Illinois, a homicide rate of 52.6

South Chicago, formerly known as Ainsworth, a homicide rate of 48.

Belize , a homicide rate of  44.7.

El Salvador, a homicide rate of  41.2. 

Guatemala, a homicide rate of  39.9. 

How to join the richest 5 percent of Americans?

How to join the richest 5 percent of Americans?

 

Making  $206,568 or more.

When your policies never fail?

When your policies never fail?


When you find our patience always waiting. 

How much was the spending on Medicare drugs on 2014?

How much was the spending on Medicare drugs on 2014?

$121 billon, $2.5 billion on a single antipsychotic medicine, Abilify.

Why do you think that more government will transform minds in a new way?

Why do you think that  more government will transform minds in a new way?

 

Because you believe that a car will run better with more gasoline.

Why is America struggling with wealth distribution ?

Why is America struggling with wealth distribution ?

 

Because it is too much government-engineered.

How the jobs will be in the next decade?

How the jobs will be in the next decade?

 

Of the 15 occupations with the most projected job growth, only four will ask for a bachelor’s degree; eight will require no formal education credentials and nine will offer median annual wages under $30,000.

Why the elites are hated by Americans?

Why the elites are hated by Americans?

Because the elites have become professionals

How to run your life?

How to  run your life?

 

You need the ability to focus and prioritize and compartmentalize...and you need great people around you.

How much money current workers and retirees are projected to receive from Social Security?

How much money current workers and retirees are projected to receive from Social Security?

 

Current workers and retirees are projected to receive $59 trillion according the Social Security trustees, almost three times the   net worth of 90% of households in America, a net worth of about $20 trillion.

Why doesn't exist economic growth in the U.S.?

Why doesn't exist economic growth in the U.S.?

 

Because every dollar you save your customer is a dollar you have taken from some other player in the ecosystem.

How much money current workers must pay for future payroll taxes before retirement?

How much money current workers must pay for future payroll taxes before retirement?

$25 trillion with a present actuarial value.

How to maintain jobs and incomes for workers with modest education and skills?

How to maintain jobs and incomes for workers with modest education and skills?

 

Increasing the cost of forming not  functioning families and reducing entitlements.

How many people are killed by pain killers?

How many people are killed by pain killers?

 

48 people are killed by pain killers every day in the U.S.

When a country becomes a declining country?

When a country becomes a declining country?
When the country is no longer willing - or able to deploy power on behalf of its interest.

Why Medicare, the largest single U.S. payer for prescription drugs doesn't bargain with drug companies?

Why Medicare, the largest single U.S. payer for prescription drugs doesn't bargain with drug companies?

Because Medicare is by law unable to negotiate pricing.

When the Supreme Court doesn't have the courage of their convictions?

When the Supreme Court doesn't have the courage of their convictions?
When  their convictions threaten entrenched political interests.

Why does the rate of new-business formation has fallen for a couple decades in a row?

Why does the rate of new-business formation has fallen for a couple decades in a row?
Because innovation output is largely free or nearly free.

What percentage of low-income high-school grads are enrolled in two- or four-year college programs?

What percentage of low-income high-school grads  are enrolled in two- or four-year college programs?

45.5% of low-income, recent high-school graduates were enrolled in college in 2013, compared with 55.9% in 2008.

How to feed the hysteria?

How to feed the hysteria?


With alarms.

What is the average net profit margin of pharmaceutical and biotechnology companies in the S&P 1500?

What is the average net profit margin of pharmaceutical and biotechnology companies in the S&P 1500?

 

16% and 7% for all companies in the index.

What is the biggest scarcity in the human being?

What is the biggest scarcity in the human being?

Willingness and discipline

How much money does it cost to build a gas station if the builder is the Pentagon ?

How much money does it cost to build a  gas station if the builder is the Pentagon ? 
$43 million acording the Special Inspector General for Afghanistan Reconstruction.

Why technological growth doesn't need basic scientific research?

Why technological growth doesn't need basic scientific research?

Because it happens spontaneously though the interaction of many ordinary people.

How many people are in the U.S. suspected of terror ties?

How many people are  in the U.S. suspected of terror ties?

 

More than 900 people in the U.S. are suspected of terror ties according FBI Director James Comey.

What happens when events reach the point where significant interests are at stake?

What happens when events reach the point where significant interests are at stake?
They require a more substantial response.

When assumptions prove to be wrong?

When assumptions prove to be wrong?
When problems of others become your problems as well.

How much in additional taxes per hour recommends an IRS auditor?

How much in additional taxes per hour recommends an IRS auditor?
An IRS auditor working tax returns cases for people with incomes between $200,000 and $400,000, recommends $605 in additional taxes per hour, while one working on a $5 million return will find $4,545 per hour, according to the inspector general’s report.

What is the last thing you want to hear, and possibly to believe?

What is the last thing you want to hear, and possibly to believe?
That your unwillingness to play your role has implications well beyond you.

What percentage of high-school grads are enrolled in two- or four-year college programs?

What percentage of high-school grads  are enrolled in two- or four-year college programs?

Just under 66% of recent high-school grads were enrolled in two- or four-year college programs in 2013, down from 68.6% in 2008, according to research by the American Council on Education, a higher-education industry group.

How to create loyalty that last a lifetime?

How to create loyalty that last a lifetime?

Giving a young person an opportunity

What percentage of Americans don't have landline phones?

What percentage of Americans don't have landline phones?
 
About 40% of Americans have no landline phones, up from about 2% in 2003, according to the 2014 federal National Health Interview Study.

How to operate under a set of assumptions?

How to operate under a set of assumptions?
Believing that instability can be contained.
Believing that the core order will not be affected.
Believing that  your own interest will not be threatened.

How much does the average federal employee earn?

How much does the average federal employee earn?

$84,153 in 2014—roughly 50% more than the average worker in the private economy. When you include benefits like health care and pensions, the average federal worker’s compensation rises to $119,934—nearly 80% higher than everyone else.

When a cost-benefit calculation was wrong?

When a cost-benefit calculation was wrong?
When the interests and the stakes involved are now higher than originally anticipated.

What percentage of the population age 16 and over is employed in jobs that involve primarily routine task?

What percentage of the population age 16 and over is employed in jobs that involve primarily routine task?

26% in January 2014.
It was 34% in January 2008 according the economists Henry Siu and Nir Jaimovich.

How much of its assets a mutual fund is allowed to hold in hard-to-sell-securities?

How much of its assets a mutual fund is allowed to hold in hard-to-sell-securities?

 

By regulation a mutual fund is only allowed to hold 15% of its assets in hard-to-sell-securities, a category that includes private-company shares.

Why doesn't work to try to fix societal causes?

Why doesn't work to try to fix societal causes?

 

Because it avoids responsibilities.

How many metric tons of gold has the U.S.?

How many metric tons of gold has the U.S.?

 

The U.S. has 8,134 metric tons of gold.

Germany, the second holder,  has 3,381 

Why does ideology never solve a problem?

Why does ideology never solve a problem?
Because only competency gets results.

How to present your unpalatable strategy without tamping down your position?

How to present your unpalatable strategy without tamping down your position?

 

Showing that your unpalatable strategy is the best way, at least temporarily, of tackling the problem.

Where is the point when you reach diminishing returns?

Where is the point when you reach diminishing returns?

When you do not enjoy what you are doing.

How many months on average cohabiting couples in the U.S. stay together?

How many months on average cohabiting couples in the U.S. stay together?

 

18 months.

Why the war on poverty leads to a systematic production of a perpetual underclass?

Why the war on poverty leads to a systematic production of a perpetual underclass?

Because it is a war of the government but not a war of the people.

How to displace population in the U.S.?

How to displace population in the U.S.?

 Rising home prices and attracting tech jobs in a concentration of tech firms.

When is difficult to get innovative?

When is difficult to get innovative?

When you turn technology over to someone else.

What is the main difference between a poor neighborhood and a rich neighborhood?

What is the main difference between a poor neighborhood and a rich neighborhood?

 

The family structure according to a research team headed by MIT's David Autor

How many student borrowers are in America?

How many student borrowers are in America?

43.34 million. 13.5% of the population.

Why insecurity rises and opportunity contracts?

Why  insecurity rises and opportunity contracts?

Because too many people  expect everything must be taken care of for someone else